Accuracy Profiles for Analyzing Residual Solvents in Textiles by GC-MS

Determination of residual solvents in pharmaceuticals by thermal desorption-GC/MS.

A novel method for the determination of residual solvents in pharmaceuticals by thermal desorption (TD)-GC/MS has been established. A programmed temperature pyrolyzer (double shot pyrolyzer) is applied for the TD. This method does not require any sample pretreatment and allows very small amounts of the sample. Directly desorbed solvents from intact pharmaceuticals (ca. 1 mg) in the desorption c...

A validated GC-MS method for the determination and quantification of residual solvents in counterfeit tablets and capsules.

A fast headspace GC-MS method was developed and validated for the detection and quantification of residual solvents of all three ICH-classes in counterfeit tablets and capsules. The method was validated for 10 solvents, selected based on an initial screening of counterfeit medicinal products. The considered solvents were ethanol, 2-propanol, acetone, ethylacetate, chloroform, carbon tetrachlori...

A Generic Method for the Analysis of Residual Solvents in Pharmaceuticals Using Static Headspace-GC-FID/MS

The determination of residual solvents in pharmaceuticals is one of the most important gas chromatography (GC) applications in quality assurance/quality control (QA/QC) in the pharmaceutical industry. Sample introduction is normally done using static headspace (SHS). In routine QC, GC with flame ionization detection (FID) is preferred, while mass spectrometry (MS) can be used for screening and ...

Aromatic profiles of Thymus hyemalis and Spanish T. vulgaris essential oils by GC–MS/GC–O

Thymus hyemalis L. and Spanish T. vulgaris subsp. vulgaris shrubs are characterized by a great chemical intraspecific variability among plants. This fact makes it difficult to detect real changes occurring in their essential oil composition during the vegetative cycle. Because of this, clones of T. hyemalis and T. vulgaris were used to monitor seasonal variations in their aromatic composition o...

Volatile Profiles of Honeys Using HS-SPME-GC-MS